Furthermore, one systemic study investigating the changes in renal transporter expressions in patients of various chronic liver diseases revealed that the protein expression of OAT3 was significantly decreased in NASH (nonalcoholic steatohepatitis), ALD (alcohol-associated liver disease), HCV (viral hepatitis C), and combined ALD/HCV. This evidence concerns the gene SLC22A8 and metabolic dysfunction-associated steatohepatitis.