DLGAP4 and ethylmalonic encephalopathy: Based on our previous study on the antibacterial activity and mechanism of DLP4 against S. hyicus [25], we investigated the anti-biofilm activity of DLP4 against S. hyicus ACCC 61734 in vitro, established the piglet EE model caused by S. hyicus infection, and systematically evaluated the potential therapeutic effect of DLP4 on EE in piglets.