As shown in Figure 9, after infection with S. hyicus ACCC 61734, the histopathological findings of piglet skin showed typical skin pathological features of EE, the Dsg1 between the keratinocytes of the epidermal granular layer of the skin was digested, the connection between the cells was broken, and the skin tissue section showed obvious gaps (Figure 9), which mainly attributed to the following development and progression of EE. The gene discussed is DSG1; the disease is infection.