CXCL8 and gastroesophageal reflux disease: In this context, it is important to note that the modulation of the TLRs signaling pathway has been raised as a potential therapeutic approach in several GI diseases [26]; a reduction in gastric inflammation by traditional medicines in gastritis has also been reported, for example, the hydroethanolic extract of Rosa damascena showed a strong reduction in IL-8 secretion in Helicobacter pylori-infected cells [28] and, as abovementioned, rose oil capsules reduced symptoms in GERD in a clinical trial.