Further advancing targeted delivery for glioma therapy, a study developed chitosan-PLGA nanoparticles functionalized with AS1411 aptamer, targeting nucleolin overexpressed on brain cancer cells, and RGD peptide, to enhance the targeted co-delivery of docetaxel (DTX) and up conversion nanoparticles (UCNP) for brain cancer therapy and imaging [181]. Here, NUCLEOLIN is linked to brain cancer.