It can be inferred that SGLT2 inhibitors diminish NaHCO3 reabsorption by inhibiting the Na+/H+ exchanger-3 (NHE3) in the renal proximal tubules while enhancing chloride reabsorption, leading to acidosis due to the reduction in NaHCO3 reabsorption, resulting in ketoacidosis in the absence of hyperglycemia. Here, SLC5A2 is linked to Hyperglycemia.