SLC9A3 and Hyperglycemia: It can be inferred that SGLT2 inhibitors diminish NaHCO3 reabsorption by inhibiting the Na+/H+ exchanger-3 (NHE3) in the renal proximal tubules while enhancing chloride reabsorption, leading to acidosis due to the reduction in NaHCO3 reabsorption, resulting in ketoacidosis in the absence of hyperglycemia.