CXCL8 and chronic obstructive pulmonary disease: In contrast, in both asthma and COPD, naturally occurring and RV-induced experimental exacerbations are associated with an increase in tissue neutrophils as well as eosinophils [12,13,14,15,16], also of interleukin-8 (IL-8,CXCL8) [12,15] and CC-type chemokine ligand 5 (CCL5) gene expression [14].