Therefore, considering the potential roles of the IL-13/IL-13Rα2 pathway in osteogenesis and its roles in the development and progression of osteosarcoma, this study aimed to explore the expression and roles of IL-13Rα2 in the progression of osteosarcoma by evaluating the expression of IL-13Rα2 in human osteosarcoma tissue samples and cell lines. The gene discussed is IL13RA2; the disease is osteosarcoma.