Finally, it was found that berberine may inhibit the proliferation and inflammatory reaction of RA-FLS cells by affecting the binding rate of the PPARγ-NF-κB complex, the expression of CREB and EGR-1, the biogenesis and maintenance of organelles, and cell phagocytosis, thus exerting its therapeutic effect on RA. This evidence concerns the gene CREB1 and rheumatoid arthritis.