The secretion of inflammatory cytokines such as IL-6, chemokine IL-8, monocyte chemoattractant protein 1, and matrix metalloproteinases pro-MMP1 and MMMP3 increased in a dose-dependent way as the synovial fibroblasts of RA received stimulation with palmitic acid and linoleic acid [30]. This evidence concerns the gene IL6 and rheumatoid arthritis.