IL1B and gout: The innate immune system plays a vital role in this process; the identification of MSU crystals by phagocytic cells, such as macrophages, activates the NLR inflammasome (NLRP1, NLRP3, NLRP6, NLRP7, NLRC4, NLRC5 and NAIP2/5/6), leading to the secretion of pro-inflammatory cytokines like interleukin-1β (IL-1β), which orchestrates the typical symptoms of gout, including severe joint pain, swelling, and erythema [18].