Circ-SIRT1 delivery sponges miR-3681-3p/5195-3p and miR-132/212 to stabilize SIRT1 protein from degradation and enhance SIRT1 expression, inhibiting cardiac hypertrophy and ameliorating VSMC inflammation via SIRT1/NF-κB signaling [192,193]. This evidence concerns the gene SIRT1 and cardiac hypertrophy.