By promoting mitochondrial biogenesis, structural integrity, antioxidant protein expression, and the destruction of dysfunctional ROS-producing mitochondria via mitophagy, SIRT1 ameliorates oxidative stress-induced myocardial hypertrophy, MEC injury, and apoptosis [35,40,41,42,43,44]. Here, SIRT1 is linked to cardiac hypertrophy.