For instance, lncRNA KCNQ1OT1 aggravates cerebral infarction by sponging miR-16-5p, leading to polypyrimidine tract binding protein 1 activation and subsequent SIRT1 downregulation in BMECs associated with inflammation and diminished angiogenesis [65]. The gene discussed is KCNQ1OT1; the disease is cerebral infarction.