AXL and melanoma: For instance, Lornoxicam (a selective COX-2 inhibitor), Aspirin, and Acetaminophen can inhibit melanoma metastasis and recurrence by inhibiting the formation of the Hsp90-CDC37 complex, leading to the misfolding of AXL, thus initiating the ubiquitination–proteasome system (UPS) to degrade AXL [23].