In contrast, Kanders et al. [57], in a study with 150 Swiss MDD patients, found that the CYP2C19*17 CC genotype carriers had higher scores on the CES-D scale (Center for Epidemiologic Studies Depression Scale) compared to the *17 CT and TT genotypes, implying a possible association with MDD severity. This evidence concerns the gene CYP2C19 and major depressive disorder.