Relevant to the amyloid cascade hypothesis, β-site amyloid precursor protein cleaving enzyme-1 (BACE1, also known as β-secretase or memapsin 2) is an enzyme primarily known for its role in the amyloidogenic pathway leading to the production of Aβ peptides, which are implicated in the pathogenesis of AD [8,9]. The gene discussed is BACE1; the disease is Alzheimer disease.