Considering the 6-month dynamic effect of IBD treatment on some of the potential confounders, binary logistic regression was repeated with dependent variable the change in steatosis status “no steatosis” (including patients that remained without steatosis and those that regress steatosis) vs. steatosis (including patients with persistent steatosis), and potential confounders the biologics (group), the change in IBD activity, disease duration, age, and changes in adiponectin, TNF, leptin, PIINP, and/or TIMP-1 (endpoint minus baseline). The gene discussed is LEP; the disease is steatosis.