The top 20 identified targets were AKT1, TP53, TNF, IL6, CTNNB1, SRC, MYC, EGFR, VEGFA, JUN, MAPK3, IL1B, STAT3, HSP90AA1, CASP3, PTEN, ESR1, HIF1A, EGF, and CCND1 (Table S3, including their full names), which are primarily associated with apoptosis in liver cancer cell lines. The gene discussed is ESR1; the disease is liver cancer.