Specifically, 10 potential therapeutic targets (AKT1, CASP3, IL6, JUN, MYC, MAPK3, SRC, STAT3, TNF, TP53) were directly linked to the KEGG pathway “hepatitis B” and were associated with 21 compounds (SQ7, ZJ11, ZJ3, ZJ4, CBM9, CF2, CF3, QYS8, QYS9, ZJ8, CL3, CL5, ZZS1, CL2, DSL4, ZJ10, ZJ6, DSL5, JTS1, TM12, XYS18; Table S2). This evidence concerns the gene MAPK3 and hepatitis B virus infection.