This study demonstrated that both DeGT and RGT treatments for 8 weeks effectively reduced energy intake, fat mass, high blood pressure, inflammatory (TNF-α in adipose tissue) and obesity (serum L/A ratio, serum corticosterone, 11βHSD1 in adipose tissue) markers, as well as histomorphometry changes (adipocyte hypertrophy, Bowman’s space area and glomerular atrophy). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.