TLR4 and cardiovascular disorder: To elucidate this, Tanshinone IIa, the most actively investigated constituents of Danshen, has been reported to possess a wide range of therapeutic effects in cardiovascular diseases [8], and its anti-inflammatory effects include the downregulation of the Toll-like receptor 4 (TLR4)/NF-κB pathway and the inhibition of nitric oxide (NO), interleukin (IL)-1β, IL-6 and TNF-α [49].