SHBG and Infertility: The main sex-steroid hormones that are linked by SHBG are testosterone, 5α-dihydrotestosterone, and 17β-estradiol; however, SHBG has shown affinity for synthetic steroids and also for environmental contaminants [93,94,95], which could alter the concentration of SHBG or induce its dysfunction with a consequent adverse reproductive effect, such as infertility [96].