Similarly, the p.Leu997Phe (L997F) PV could be correlated with CFTR-related disorders (CFTR-RD), but when it is presented as a complex allele with the variant p.(Arg117Leu) (R117L) (Table S1), this combination could produce a mild CF phenotype [11]. The gene discussed is CFTR; the disease is cystic fibrosis.