Specifically, NPC1L1 downregulation may reflect a metabolic adaptation in RCC development, where the Warburg effect shifts energy production towards glycolysis, and the effective capabilities of SR-B1 and VLDL-R to transfer cholesterol in bulk from HDL and VLDL—unlike the absorption of individual cholesterol molecules by NPC1L1—adequately meets the tumor’s initial cholesterol demands. This evidence concerns the gene SCARB1 and renal cell carcinoma.