On the contrary, the overexpression of the m6A demethylase AlkB homolog 5 RNA demethylase (ALKBH5) significantly enhanced TIALD expression, while YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) and YTH domain containing 1 (YTHDC1) accelerated TIALD degradation in HCC cells (SMMC-7721 and SNU449) [107]. Here, ALKBH5 is linked to hepatocellular carcinoma.