By exploring the expression profiles of HCC circRNAs, miRNAs, and mRNAs in TCGA and the Gene Expression Omnibus (GEO) databases, the authors identified a circRNA-miRNA-hub gene regulatory network, including seven target hub genes (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 [CITED2], Acyl-CoA synthetase long-chain family member 4 [ACSL4], Myristoylated alanine-rich protein kinase C substrate [MARCKS], Kinesin family member 5B [KIF5B], AURKA, Smoothened, frizzled class receptor [SMO], and Ras homolog family member A [RHOA]). This evidence concerns the gene KIF5B and hepatocellular carcinoma.