IDH1 and central nervous system cancer: Kesler’s studies in Cooman et al.’s review on IDH1-mutant and IDH1-WT malignant astrocytomas showed that IDH-WT gliomas are associated with a higher cognitive load than IDH-Mut tumours, and that the brain connectivity of IDH1-WT tumours is lower than that of IDH1-mutant gliomas, particularly in medial frontal, posterior parietal, and subcortical sites [17,19,21,22,23].