Male gender, advanced age, stage increase, plaque lesions, raised lactate dehydrogenase and ß2 microglobulin levels, blood eosinophilia, folliculotropism, and large-cell transformation in pathology have been defined as poor prognostic factors; conversely, characteristics like patch lesions, hypopigmentation, poikiloderma, lymphomatoid papulosis, and CD8 positivity in immunohistochemical analyses are defined as favorable prognostic factors [4,7,9,42,43,44]. The gene discussed is CD8A; the disease is Lymphomatoid Papulosis.