Interestingly, the authors reported an increase from 3.5 to 6.5% in significant PCa detection when serum PSA levels ranged between 2.1 and 3.0 ng/mL, and from 0.7 to 1% when serum PSA levels were lower than 2.1 ng/mL [35]. This evidence concerns the gene KLK3 and posterior cortical atrophy.