These vectors employ an engineered cone opsin promoter to drive the expression of CNGA3 (rAAV2tYF-PR1.7-hCNGA3) in patients with CNGA3-associated ACHM and CNGB3 (rAAV2tYF-PR1.7-hCNGB3) in patients with CNGB3-associated ACHM. The gene discussed is CNGA3; the disease is achromatopsia.