In relation to the above, the resemblance in the immunophenotype between the Th-17-high asthma phenotype and psoriasis is supported by genetic studies in which, for example, genes expressed in asthma patients with high IL-17 levels were common with those reported to be altered in psoriatic lesions, including genes regulating epithelial barrier function and defensive mechanisms [50]. The gene discussed is IL17A; the disease is psoriasis.