REN and obesity due to melanocortin 4 receptor deficiency: Age, obesity, metabolic syndrome, insulin resistance, diabetes mellitus, catecholamines, renin, aldosterone, cortisol, melatonin, abnormal neurohormonal regulation, which is characterized by an imbalance between sympathetic and parasympathetic nervous system tone, insufficient physical activity, irregular eating patterns, increased sodium consumption, and tobacco use are some extrinsic and intrinsic factors that contribute to the development of a non-dipper blood pressure [9,10,37,38,39,40,41,42,43,44,45,46,47,48,49].