HLA-DRB1 and sarcoidosis: At the same time, the HLA-DRB1*04/*15 genes are associated with the risk of developing extrapulmonary manifestations of sarcoidosis, such as lesions of the skin, superficial lymph nodes, eyes, nervous system, kidneys, parotid and salivary glands, heart, liver, spleen, and bone marrow [117].