Interestingly, because miRNA-133a indirectly targets antihypertrophic genes including guanosine triphosphate-guanosine diphosphate (GDP-GTP) exchange protein, Rhoa, signal transduction kinase cell division control protein 42 (Cdc42), and the nuclear factor negative elongation factor complex member A (Nelfa/Whsc2), miRNA-133a downregulation is involved in the process of cardiac hypertrophy [34]. This evidence concerns the gene CDC42 and cardiac hypertrophy.