In a univariate Cox proportional hazard ratio analysis, the presence of depression on the HAM-D scale (HR: 4.91, 95% CI: 1.97–12.24, p < 0.001), a BDI score ≥ 11 points (3.61, 1.64–8.0, 0.001), diabetes on insulin (3.02, 1.21–7.53, 0.018), use anticoagulants, either NOAC or VKA (2.38, 1.10–5.14, 0.028), atrial fibrillation (2.71, 1.25–5.87, p = 0.011), and creatinine level ≥ 130 μmol/L (2.86, 1.15–7.12, p = 0.024) showed associations with a MACCE risk (Table 5, Figure 2). This evidence concerns the gene INS and major depressive disorder.