In a prospective cohort study of 7343 pregnant women to investigate the association of thrombophilia with placenta-mediated pregnancy complications, there were 507 (6.9%) women with FVL and or prothrombin gene mutations (PGMs); FVL and PGMs were associated with a relative risk of 1.04 (95% CI, 0.81–1.33) [17,18]. This evidence concerns the gene F5 and Rare hereditary thrombophilia.