Their study found that patients diagnosed before 2014 had a longer duration of symptoms before diagnosis, larger pituitary adenomas, a higher incidence of cavernous sinus infiltration, higher levels of GH and IGF-I, and a more frequent incidence of comorbidities such as colorectal polyps and thyroid cancer at diagnosis, in comparison to those diagnosed in the last decade [40]. This evidence concerns the gene GH1 and polyp of large intestine.