Of note, the activating CTNNB1 gene mutations are mostly located in the ubiquitination recognition motif of the CTNNB1 gene, which is different to that of desmoid fibromatosis (typically involving exon 3, encoding the phosphorylation domain of CTNNB1), although occasional SNM cases have also reported exon 3 CTNNB1 mutation [3]. This evidence concerns the gene CTNNB1 and desmoid tumor.