A study involving 565 patients from the Pulmonary Hypertension Association Registry (United Kingdom) concluded that the 6MWD and B-type natriuretic peptide (BNP)/N-terminal proBNP levels were also significantly associated with EmPHasis-10 questionnaire scores both at baseline and over time [33]. The gene discussed is NPPB; the disease is pulmonary arterial hypertension.