CRP and obesity due to melanocortin 4 receptor deficiency: In contrast, non-elevated CRP and IL-6 levels in OSA patients might be attributed to the milder OSA severity and lower body weight in the cohort suggesting that elevated CRP may be more related to obesity than OSA.However, elevated IL-1β, a marker of systemic inflammation, and fibrinogen in mild-to-moderate OSA patients, consistent with most reports, and MAD therapy significantly decreased IL-1β, indicating reduced systemic inflammation, similar to CPAP results.