The aims of our study are to: (1) assess the disease specificity of anti-DSG2-ab in ARVC, myocarditis, and other extracardiac immune-mediated diseases, (2) assess the correlation of AIDA-positive status by IFL and anti-DSG2-ab detection by ELISA, and (3) to assess the clinical and/or prognostic correlates of anti-DSG2-abs in ARVC. Here, DSG2 is linked to myocarditis.