DSC2 and Arrhythmogenic right ventricular dysplasia: In the ARVC classical form, mutations involve genes encoding desmosome proteins, such as Desmoglein 2 (DSG2) [5], Plakophilin 2 (PKP2), Plakoglobin (JUP) [6], Desmoplakin (DSP) [7], and Desmocollin 2 (DSC2) [8].