From a clinical perspective, in our study, anti-DSG2-ab status did not correlate with worse clinical and/or morphofunctional features in ARVC patients; on the other hand, in ARVC, it was AIDA positivity that led to a higher probability of being AHA-positive, presenting more pre-syncope and abnormalities in cardiac rhythm than ARVC AIDA-negative counterparts. This evidence concerns the gene DSG2 and Arrhythmogenic right ventricular dysplasia.