Currently, the use of markers such as Ki67, p16, CK 13/14, or p53 is widely known to assess the regressive or progressive character of a high-grade squamous intraepithelial lesion (CIN2, CIN3) [68], with dual p16/Ki67 immunostaining representing an important test in the diagnostic evaluation of a persistent HPV lesion. This evidence concerns the gene MKI67 and squamous cell intraepithelial neoplasia.