PTGS2 and epilepsy: The significant increase in predictive diagnostic value of combining the two studied ASD biomarkers, COX-2 and IHh, as well as our understanding of their roles in glutamate excitotoxicity and neuroinflammation as two confirmed etiological mechanisms of ASD, suggests that these variables may be useful diagnostic markers for ASD in addition to epilepsy and gastrointestinal problems, which are common comorbidities.