In a multivariate logistic regression analysis, Yang S. et al. [33] showed an AUC of 0.96, with an overall accuracy, sensitivity, and specificity of 93.4%, 96.3%, and 83.8%, respectively, for four clinical and biological predictors (age ≤ 49 months, primary site of tumour adrenal and thoracic, NSE level ≥ 33 ng/mL, and tumour encasing blood vessel) to predict the diagnosis of malignant peripheral neuroblastic tumours (PNTs) [33]. Here, ENO2 is linked to neoplasm.