IFNB1 and Herpesviridae infectious disease: Additionally, Li et al. have found that enhanced ALKBH5 lactylation at lysine K284 during herpesvirus infections mediates the m6A demethylation of interferon-beta (IFN-β) mRNA and facilitates IFN-β mRNA biogenesis, which in turn contributes to the antiviral innate immunity [150].