COVID-19+ PLWH with a detectable VL (n = 18) had significantly lower percentages of CD4+ (p = 0.008), CD8+ EM4 CD57+ (p = 0.013), and CD8+ TEMRA pE1 T-cells expressing PD-1 (p = 0.005) than COVID+ PLWH with an undetectable VL (n = 19). This evidence concerns the gene B3GAT1 and COVID-19.