This aligns with Nkosi et al. and Chanda et al., who found diminished cellular responses and lower frequencies of SARS-CoV-2-specific IFN-γ-producing CD4+ T-cells in PLWH with a detectable HIV VL, leading to weakened immune responses to SARS-CoV-2 and, thus, a higher susceptibility to severe disease, poorer COVID-19 outcomes, and mortality [23,48]. Here, CD4 is linked to COVID-19.