DNMT3A and acute myeloid leukemia: In a study of evaluation of DNMT3A genetic polymorphisms as outcome predictors in acute myelogenous leukemia (AML), multivariate analysis and combined genotype analysis showed that rs2276598 was associated with increased chemosensitivity (p < 0.05), and this SNP was significantly associated with disease prognosis (p < 0.05) [17].