Interestingly, in both the adenocarcinoma group (not subset by primary site) and the esophageal adenocarcinoma (EC) group, a significantly higher proportion of females (22.5% and 28.2%, respectively) displayed a temperature-sensitive TP53 mutation with activity greater than 50% at both 32 °C and 37 °C, compared to males (14.5% and 14.3%, respectively). This evidence concerns the gene TP53 and esophageal adenocarcinoma.