Univariable and multivariable logistic models showed that after adjusting for other known risk factors, FGF21 (≥377.50 ng/mL vs. <377.50 ng/mL) and NT-proBNP (≥2379 pg/mL vs. <2379 pg/mL) were independent predictors for advanced HF, with elevated values of FGF21 or NTproBNP being significantly associated with increased odds of advanced HF in all tested models (Table 5). The gene discussed is FGF21; the disease is hydrops fetalis.