Lenart-Lipinska et al., 2013 [43] obtained a median value of FGF21 = 240.7 pg/mL in patients with T2DM and demonstrated that FGF21 levels above the median value correlated with an increased incidence of CV events such as heart failure, myocardial infarction, stroke and coronary revascularization during a 2-year period of follow up, with an HR of 4.7 [43]. Here, FGF21 is linked to heart failure.