Overactivation of mineralocorticoid receptors (MR) may occur in the context of aldosterone excess or in the context of modulation of mineralocorticoid receptor expression secondary to different pathological conditions (such as diabetes, CKD with elevated proteinuria, heart failure, myocardial infarction, hypertension, vascular aging, or cerebral aneurysm) [41]. The gene discussed is NR3C2; the disease is heart failure.