SLC5A2 and type 2 diabetes mellitus: In addition to the hypoglycemic effect, several studies have shown that SGLT2-i have a pleiotropic outcome in preventing hospitalization and death in T2DM patients through the nephroprotective and cardiovascular protective role and anti-inflammatory effects but with some alerts connected to amputation risk [6] whose importance has been outlined and discussed in detail in some reviews [7,8].