KLK3 and cancer: Disease progression occurred in 237 (22.6%) patients who were more likely to present with PSA levels higher than 10 ng/mL, palpable cancers with higher percentages of BPCs, and grade groups beyond ISUP 3, as well as with a higher 2012 Briganti nomogram score (7.0%, 2.5–17.0% vs. 3.0%, 2.0–6.0%) compared to their non-progressing counterparts (Table 2).