Nevertheless, molecular studies play a vital role in verifying angiomatoid fibrous histiocytoma (AFH); thus, immunohistochemistry demonstrates positivity for desmin, CD68, and CD99, whereas cytogenetic evaluation demonstrates that the EWSR1-CREB1 fusion gene is present in a majority of AFH cases as addressed above [16,17]. The gene discussed is CREB1; the disease is histiocytoma, Angiomatoid fibrous.