However, despite a high frequency of IMNM characteristics at muscle biopsy in scleromyositis patients, these patterns are shown to be associated with anti-Ku, anti-PM/SCL, and anti-U1-RNP autoantibodies, rather than with anti-SRP or anti-HMGCR antibodies [12]. This evidence concerns the gene UCN2 and Scleroderma Polymyositis Overlap Syndrome.