A skin and muscle biopsy was performed, after a reasonable disclosure [51] in light of the patient’s fatigue, the cardiac episode in November 2022, the elevated CK and CK-MB values in recent months, positive anti-SRP antibodies, muscle atrophy, and the suspicion of immune necrotizing myopathy overlapping systemic sclerosis or maybe a scleromyositis. This evidence concerns the gene UCN2 and systemic sclerosis.