There was also a negative impact of creatinine (β = −0.476, p < 0.001), uric acid (β = −0.277, p = 0.010), β2-microglobulin (β = −0.224, p = 0.040), and iPTH (β = −0.314, p = 0.003) on the quality of life in patients with CKD stage 3–4. This evidence concerns the gene HLA-G and chronic kidney disease.